| 2021-08-14 15:00:3914/08/2021 |   Brighouse Town v Dunston | 15:00:3915:00 | 0 - 0 | Yorkshire Payments Stadium | Recap |
| 2021-08-17 19:45:0417/08/2021 |  Frickley Athletic vs Brighouse Town AFC | 19:45:0419:45 | 2 - 1 | | Recap |
| 2021-08-23 19:45:0923/08/2021 |  Brighouse Town AFC vs Sheffield FC | 19:45:0919:45 | 2 - 2 | Yorkshire Payments Stadium | Recap |
| 2021-08-30 15:00:1630/08/2021 |  Brighouse Town AFC vs Ossett United | 15:00:1615:00 | 2 - 0 | Yorkshire Payments Stadium | Recap |
| 2021-09-07 19:45:5907/09/2021 |  Pickering Town vs Brighouse Town AFC | 19:45:5919:45 | 2 - 2 | | Recap |
| 2021-09-11 15:00:0811/09/2021 |  Brighouse Town AFC vs Pontefract Collieries | 15:00:0815:00 | 1 - 1 | Yorkshire Payments Stadium | Recap |
| 2021-09-13 19:45:3513/09/2021 |  Brighouse Town AFC vs Bridlington Town | 19:45:3519:45 | - | Yorkshire Payments Stadium | Preview |
| 2021-09-18 15:00:1818/09/2021 |  Hebburn Town vs Brighouse Town AFC | 15:00:1815:00 | - | | Preview |
| 2021-10-02 15:00:0302/10/2021 |  Marske United vs Brighouse Town AFC | 15:00:0315:00 | - | | Preview |
| 2021-10-04 19:45:3304/10/2021 |  Brighouse Town AFC vs Stocksbridge Park Steels | 19:45:3319:45 | - | Yorkshire Payments Stadium | Preview |
| 2021-10-16 15:00:3516/10/2021 |  Shildon vs Brighouse Town AFC | 15:00:3515:00 | - | | Preview |
| 2021-10-23 15:00:2123/10/2021 |  Brighouse Town AFC vs Worksop Town | 15:00:2115:00 | - | Yorkshire Payments Stadium | Preview |
| 2021-11-06 15:00:2406/11/2021 |  Cleethorpes vs Brighouse Town AFC | 15:00:2415:00 | - | | Preview |
| 2021-11-13 15:00:4513/11/2021 |  Brighouse Town AFC vs Tadcaster Albion | 15:00:4515:00 | - | Yorkshire Payments Stadium | Preview |
| 2021-11-20 15:00:3620/11/2021 |  Lincoln United vs Brighouse Town AFC | 15:00:3615:00 | - | | Preview |
| 2021-11-27 15:00:3627/11/2021 |  Brighouse Town AFC vs Yorkshire Amateur | 15:00:3615:00 | - | Yorkshire Payments Stadium | Preview |
| 2021-12-04 15:00:4204/12/2021 |  Stockton Town vs Brighouse Town AFC | 15:00:4215:00 | - | | Preview |
| 2021-12-11 15:00:4111/12/2021 | Brighouse Town AFC vs Frickley Athletic | 15:00:4115:00 | - | Yorkshire Payments Stadium | Preview |
| 2021-12-18 15:00:3518/12/2021 | Dunston FC vs Brighouse Town AFC | 15:00:3515:00 | - | | Preview |
| 2021-12-27 15:00:1727/12/2021 |  Brighouse Town AFC vs Liversedge | 15:00:1715:00 | - | Yorkshire Payments Stadium | Preview |
| 2022-01-01 15:00:3001/01/2022 | Ossett United vs Brighouse Town AFC | 15:00:3015:00 | - | | Preview |
| 2022-01-08 15:00:3608/01/2022 | Brighouse Town AFC vs Marske United | 15:00:3615:00 | - | Yorkshire Payments Stadium | Preview |
| 2022-01-15 15:00:1815/01/2022 | Stocksbridge Park Steels vs Brighouse Town AFC | 15:00:1815:00 | - | | Preview |
| 2022-01-22 15:00:2622/01/2022 | Brighouse Town AFC vs Shildon | 15:00:2615:00 | - | Yorkshire Payments Stadium | Preview |
| 2022-01-29 15:00:3729/01/2022 | Worksop Town vs Brighouse Town AFC | 15:00:3715:00 | - | | Preview |
| 2022-02-05 15:00:1705/02/2022 | Brighouse Town AFC vs Cleethorpes | 15:00:1715:00 | - | Yorkshire Payments Stadium | Preview |
| 2022-02-08 19:45:0608/02/2022 | Tadcaster Albion vs Brighouse Town AFC | 19:45:0619:45 | - | | Preview |
| 2022-02-19 15:00:5419/02/2022 | Bridlington Town vs Brighouse Town AFC | 15:00:5415:00 | - | | Preview |
| 2022-02-26 15:00:0626/02/2022 | Brighouse Town AFC vs Hebburn Town | 15:00:0615:00 | - | Yorkshire Payments Stadium | Preview |
| 2022-03-12 15:00:0112/03/2022 | Pontefract Collieries vs Brighouse Town AFC | 15:00:0115:00 | - | | Preview |
| 2022-03-19 15:00:3219/03/2022 | Brighouse Town AFC vs Pickering Town | 15:00:3215:00 | - | Yorkshire Payments Stadium | Preview |
| 2022-03-26 15:00:4426/03/2022 | Yorkshire Amateur vs Brighouse Town AFC | 15:00:4415:00 | - | | Preview |
| 2022-04-02 15:00:5902/04/2022 | Brighouse Town AFC vs Lincoln United | 15:00:5915:00 | - | Yorkshire Payments Stadium | Preview |
| 2022-04-09 15:00:5809/04/2022 | Sheffield FC vs Brighouse Town AFC | 15:00:5815:00 | - | | Preview |
| 2022-04-18 15:00:5218/04/2022 | Liversedge vs Brighouse Town AFC | 15:00:5215:00 | - | | Preview |
| 2022-04-23 15:00:0923/04/2022 | Brighouse Town AFC vs Stockton Town | 15:00:0915:00 | - | Yorkshire Payments Stadium | Preview |
Brighouse Town AFC vs Harrogate Town
Brighouse Town AFC vs Bradford City
Brighouse Town AFC vs Matlock Town FC
Brighouse Town AFC vs Eccleshill United
Brighouse Town AFC vs Bradford Park Avenue
Brighouse Town AFC vs Farsley Celtic
