| 2021-08-14 15:00:3914/08/2021 |   Brighouse Town v Dunston | 15:00:3915:00 | 0 - 0 | Yorkshire Payments Stadium |
| 2021-08-17 19:45:0417/08/2021 |  Frickley Athletic vs Brighouse Town AFC | 19:45:0419:45 | 2 - 1 | |
| 2021-08-23 19:45:0923/08/2021 |  Brighouse Town AFC vs Sheffield FC | 19:45:0919:45 | 2 - 2 | Yorkshire Payments Stadium |
| 2021-08-30 15:00:1630/08/2021 |  Brighouse Town AFC vs Ossett United | 15:00:1615:00 | 2 - 0 | Yorkshire Payments Stadium |
| 2021-09-07 19:45:5907/09/2021 |  Pickering Town vs Brighouse Town AFC | 19:45:5919:45 | 2 - 2 | |
| 2021-09-11 15:00:0811/09/2021 |  Brighouse Town AFC vs Pontefract Collieries | 15:00:0815:00 | 1 - 1 | Yorkshire Payments Stadium |
| 2021-09-13 19:45:3513/09/2021 |  Brighouse Town AFC vs Bridlington Town | 19:45:3519:45 | 1 - 0 | Yorkshire Payments Stadium |
| 2021-09-18 15:00:1818/09/2021 |  Hebburn Town vs Brighouse Town AFC | 15:00:1815:00 | 1 - 3 | |
| 2021-10-02 15:00:0302/10/2021 |  Marske United vs Brighouse Town AFC | 15:00:0315:00 | 4 - 1 | |
| 2021-10-04 19:45:3304/10/2021 |  Brighouse Town AFC vs Stocksbridge Park Steels | 19:45:3319:45 | 2 - 1 | Yorkshire Payments Stadium |
| 2021-10-16 15:00:3516/10/2021 |  Shildon vs Brighouse Town AFC | 15:00:3515:00 | 3 - 1 | |
| 2021-10-23 15:00:2123/10/2021 |  Brighouse Town AFC vs Worksop Town | 15:00:2115:00 | 1 - 1 | Yorkshire Payments Stadium |
| 2021-11-06 15:00:2406/11/2021 |  Cleethorpes vs Brighouse Town AFC | 15:00:2415:00 | 3 - 2 | |
| 2021-11-13 15:00:4513/11/2021 |  Brighouse Town AFC vs Tadcaster Albion | 15:00:4515:00 | 1 - 1 | Yorkshire Payments Stadium |
| 2021-11-20 15:00:3620/11/2021 |  Lincoln United vs Brighouse Town AFC | 15:00:3615:00 | 1 - 1 | |
| 2021-12-04 15:00:4204/12/2021 |  Stockton Town vs Brighouse Town AFC | 15:00:4215:00 | 3 - 2 | |
| 2021-12-11 15:00:4111/12/2021 | Brighouse Town AFC vs Frickley Athletic | 15:00:4115:00 | 3 - 1 | Yorkshire Payments Stadium |
| 2021-12-18 15:00:3518/12/2021 | Dunston FC vs Brighouse Town AFC | 15:00:3515:00 | 2 - 3 | |
| 2021-12-27 15:00:1727/12/2021 |  Brighouse Town AFC vs Liversedge | 15:00:1715:00 | 1 - 2 | Yorkshire Payments Stadium |
| 2022-01-01 15:00:3001/01/2022 | Ossett United vs Brighouse Town AFC | 15:00:3015:00 | 1 - 0 | |
| 2022-01-22 15:00:2622/01/2022 | Brighouse Town AFC vs Shildon | 15:00:2615:00 | 0 - 1 | Yorkshire Payments Stadium |
| 2022-01-29 15:00:3729/01/2022 | Worksop Town vs Brighouse Town AFC | 15:00:3715:00 | 0 - 1 | |
| 2022-02-12 15:00:3612/02/2022 |  Brighouse Town AFC vs Yorkshire Amateur | 15:00:3615:00 | 1 - 2 | Yorkshire Payments Stadium |
| 2022-02-22 15:00:1722/02/2022 | Brighouse Town AFC vs Cleethorpes | 15:00:1715:00 | 0 - 2 | Yorkshire Payments Stadium |
| 2022-02-26 15:00:0626/02/2022 | Brighouse Town AFC vs Hebburn Town | 15:00:0615:00 | 3 - 1 | Yorkshire Payments Stadium |
| 2022-03-01 19:45:1801/03/2022 | Stocksbridge Park Steels vs Brighouse Town AFC | 19:45:1819:45 | 1 - 3 | |
| 2022-03-05 15:00:4705/03/2022 | Brighouse Town v Marske United | 15:00:4715:00 | 0 - 3 | Yorkshire Payments Stadium |
| 2022-03-12 15:00:0112/03/2022 | Pontefract Collieries vs Brighouse Town AFC | 15:00:0115:00 | 0 - 0 | |
| 2022-03-19 15:00:3219/03/2022 | Brighouse Town AFC vs Pickering Town | 15:00:3215:00 | 5 - 1 | Yorkshire Payments Stadium |
| 2022-03-26 15:00:4426/03/2022 | Yorkshire Amateur vs Brighouse Town AFC | 15:00:4415:00 | 1 - 3 | |
| 2022-03-29 19:45:0629/03/2022 | Tadcaster Albion vs Brighouse Town AFC | 19:45:0619:45 | 1 - 2 | |
| 2022-04-02 15:00:5902/04/2022 | Brighouse Town AFC vs Lincoln United | 15:00:5915:00 | 3 - 2 | Yorkshire Payments Stadium |
| 2022-04-05 19:45:5405/04/2022 | Bridlington Town vs Brighouse Town AFC | 19:45:5419:45 | 1 - 4 | |
| 2022-04-09 15:00:5809/04/2022 | Sheffield FC vs Brighouse Town AFC | 15:00:5815:00 | 1 - 2 | |
| 2022-04-18 15:00:5218/04/2022 | Liversedge vs Brighouse Town AFC | 15:00:5215:00 | 1 - 1 | |
| 2022-04-23 15:00:0923/04/2022 | Brighouse Town AFC vs Stockton Town | 15:00:0915:00 | 1 - 3 | Yorkshire Payments Stadium |
